Choroid plexus transport: gene deletion studies
نویسندگان
چکیده
منابع مشابه
Transport of methotrexate by the choroid plexus.
Methotrexate-3H was accumulated in vitro against a con centration gradient by the rabbit choroid plexus. This accumu lation was energy dependent, inhibited by metabolic inhibitors, and exhibited self-saturation and competitive inhibition. Several folie acid analogs with a 4-amino group were inhibitors of this accumulation, while folie and folinic acid, compounds which do not contain a 4-amino g...
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The choroid plexus epithelium is a secretory epithelium par excellence. However, this is perhaps not the most prominent reason for the massive interest in this modest-sized tissue residing inside the brain ventricles. Most likely, the dominant reason for extensive studies of the choroid plexus is the identification of this epithelium as the source of the majority of intraventricular cerebrospin...
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A stable intraventricular milieu is crucial for maintaining normal neuronal function. The choroid plexus epithelium produces the cerebrospinal fluid and in doing so influences the chemical composition of the interstitial fluid of the brain. Here, we review the molecular pathways involved in transport of the electrolytes Na+, K+, Cl-, and HCO3(-)across the choroid plexus epithelium.
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CPCs are a relatively common finding during the second trimester sonography. when a choroid plexus cyst is identified, the presence of structural malformation and other sonographic markers of aneuploidy should be assessed with a detailed fetal anatomic survey performed by an experienced person. if no other sonographic abnormalities are present, the CPC is considered isolated. given the consider...
متن کاملNa+ dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies
The choroid plexus epithelium (CPE) is located in the ventricular system of the brain, where it secretes the majority of the cerebrospinal fluid (CSF) that fills the ventricular system and surrounds the central nervous system. The CPE is a highly vascularized single layer of cuboidal cells with an unsurpassed transepithelial water and solute transport rate. Several members of the slc4a family o...
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ژورنال
عنوان ژورنال: Fluids and Barriers of the CNS
سال: 2011
ISSN: 2045-8118
DOI: 10.1186/2045-8118-8-26